Which of the following substances is mainly responsible for the depletion of the ozone layer?

The substance mainly responsible for the depletion of the ozone layer is Chlorofluorocarbon or CFC. CFCs are a type of synthetic chemical compound that is commonly used in refrigerants, air conditioning systems, and aerosol sprays. When CFCs are released into the atmosphere, they rise up to the ozone layer and react with the ozone molecules. This chemical reaction breaks down the ozone molecules, resulting in the depletion of the ozone layer. The ozone layer is an essential layer in the Earth's atmosphere that protects us from harmful ultraviolet (UV) radiation from the sun. A decrease in the ozone layer could lead to an increase in skin cancer and other negative effects on human and animal health.