The Prophet lost his wife Khadijah in the year

The Prophet Muhammad lost his wife Khadijah in the year 619 C.E.

Khadijah was the first wife of Prophet Muhammad and she played a significant role in supporting him in the early years of his prophethood. She was a successful businesswoman and a strong source of emotional and financial support for the Prophet.

In the year 619, which is known as the "Year of Sorrow," both Khadijah and the Prophet's uncle, Abu Talib, passed away. Their deaths were a great loss for the Prophet Muhammad, as they were his main sources of support and protection during that time.

Therefore, the correct answer is 619 C.E.