The characteristics that are true of most large cities are having large populations (statement I) and being commercial centres (statement IV).
By definition, large cities have large populations. This is the primary criterion that makes them "large." Additionally, most large cities serve as major commercial centres, hosting markets, businesses, industries, financial institutions, and trade activities that drive economic growth. Commerce is a near-universal feature of large urban settlements.
Statement II (administrative centres) is not true of most large cities. While some large cities serve as national or regional capitals, many do not. For example, Lagos in Nigeria is the largest city but is not the federal capital (Abuja is). Similarly, Mumbai in India is larger than New Delhi, and Sao Paulo in Brazil is larger than Brasilia. Being an administrative centre is not a defining feature of city size.
Statement III (religious centres) is even less universally applicable. While some large cities like Rome or Mecca have religious significance, the vast majority of large cities are not primarily religious centres. Religious importance is incidental, not a characteristic of most large cities.