Biotechnology is applied in the production of various useful products using biological organisms or their components. Baking industry and wine production both use biotechnology in their processes. Production of antibiotics involves the use of biotechnology to produce these drugs using microorganisms like bacteria and fungi. However, the manufacture of soap does not involve the use of biotechnology. Soap is typically made from natural or synthetic ingredients using chemical reactions rather than biological processes. Therefore, the answer is "manufacture of soap."