The main effect of comedy on an audience is laughter. Comedy is a form of entertainment that aims to make people laugh by using humor, wit, irony, satire, and other techniques. Laughter is a natural response to comedy and it has many benefits, such as reducing stress, improving mood, and strengthening social connections. When people watch or listen to comedy, they are often able to relax and let go of their worries, and they may even find themselves in a better mood afterward. Therefore, it can be said that the main effect of comedy on an audience is to make them laugh.