The first four commandments in the Bible are all about our duties to God. They teach us to have no other gods before Him, not to make idols, not to take His name in vain, and to remember the Sabbath day and keep it holy. These commandments emphasize the importance of putting God first in our lives and worshiping Him alone. They are considered foundational to the Judeo-Christian faith and serve as a guide for believers in their relationship with God.