Question 1 Report
| Base triplet | Amino acid |
|---|---|
| GCA | alanine |
| AAT | asparagine |
| CTG | leucine |
| TAC | tyrosine |
| GGT | glycine |
A short length of a gene carries the coded instructions for making part of a hormone. Table 1.1 shows five base triplets read along the coding strand of this gene and the amino acid that each triplet codes for. The cell uses this code to join amino acids together in the correct order to build the hormone.
(a) State the name given to a group of three bases that codes for one amino acid. [1]This question tests the genetic code: how the order of bases in a gene fixes the order of amino acids in a protein. Reading the code from Table 1.1 gives the answers directly.
(a) A group of three bases that codes for one amino acid is a base triplet (codon). [1]
(b) Reading each triplet from the table: GCA gives alanine, AAT gives asparagine, CTG gives leucine, so the order is alanine - asparagine - leucine. [2, 1 per two correct]
(c) Amino acids are assembled into proteins at the ribosomes (in the cytoplasm). [1]
(d) The base sequence determines the structure of the hormone as follows [4]: the order of bases forms a code [1]; each triplet of three bases codes for one particular amino acid [1]; this fixes the exact order in which the amino acids are joined together [1]; and that sequence of amino acids gives the hormone its particular structure and shape [1]. [4]
(e) The hormone has the same amino acid sequence every time because the gene has the same fixed base sequence each time it is used [1], so the same triplets code for the same amino acids in the same order [1]. [2]
(f) The sequence may differ slightly between two people because a mutation (a change in the base sequence of the gene) [1] can change one or more of the amino acids in the chain [1]. [2]
(g) One other use of proteins: as enzymes (also accept structural proteins, antibodies, or haemoglobin). [1]
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