A firm's organizational structure may change due to various reasons such as changes in the scope of business operations, mergers and acquisitions, changes in ownership, introduction of new products, changes in market conditions, and others. For instance, if a company decides to diversify its operations or enter into a new market, it may need to restructure its organization to accommodate the new business lines or market conditions. Additionally, changes in ownership, such as the death of a major partner, may also lead to a restructuring of the organization. Therefore, option D, "the scope of business operation changes," is the most appropriate answer.