'''....even though you make many prayers, I will not listen;....''
Why will God the Holy One of Israel not listen?
Answer Details
God the Holy One of Israel will not listen to their prayers because their hands are full of blood. This means that they have committed sins and have blood on their hands, yet they come to God with prayers and offerings, trying to appear righteous. Their actions and their hearts are not aligned with God's will, so their prayers and offerings are worthless. Therefore, God will not listen to them until they repent and turn away from their wicked ways.