The detoxification of urea takes place in the liver. Urea is a waste product produced by the breakdown of proteins in the liver. It is a toxic substance and needs to be removed from the body to maintain a healthy balance of nitrogenous waste products.
The liver plays a key role in the detoxification of urea by converting it into less toxic compounds, such as ammonia and then urea cycle which converts ammonia to urea. This process of urea detoxification in the liver is called the urea cycle or the ornithine cycle. The urea is then transported to the kidneys for excretion in the urine.
In summary, the liver is responsible for the detoxification of urea, a toxic waste product of protein metabolism, by converting it into less toxic compounds through the urea cycle. This process helps to maintain the proper balance of nitrogenous waste products in the body and supports overall health and wellbeing.