The component that serves as major buffer in blood is

Answer Details

The major buffer in blood is the **bicarbonate buffer system**. The bicarbonate buffer system maintains the pH of the blood and is integral for physiological homeostasis. This system primarily involves **bicarbonate ions (HCO₃^-)** and works in conjunction with carbonic acid (H₂CO₃).

In the blood, the bicarbonate buffer system works by a reversible chemical reaction:

CO₂ + H₂O ⇋ H₂CO₃ ⇋ HCO₃^- + H⁺

Here’s how it functions:

• When the pH of the blood decreases (indicating high acidity), the excess hydrogen ions (H⁺) react with **bicarbonate ions** to form **carbonic acid**, which then converts to carbon dioxide and helps to raise the pH back to normal.
• Conversely, if the blood becomes too alkaline (higher pH), **carbonic acid** can release more hydrogen ions, lowering the pH back to the normal range.

This system is exceptionally effective at buffering rapid changes in pH. The respiratory and renal systems support the bicarbonate buffer system. The lungs regulate the concentration of CO₂, and the kidneys control the concentration of HCO₃^-.

While erythrocytes (red blood cells), leucocytes (white blood cells), and lymph are components of blood, they do not play a primary role in the buffering systems of blood. The bicarbonate buffer system is primarily a chemical buffer that functions independently of these cellular components.