Hemophilia in humans is controlled by a recessive gene found on the X chromosome. This means that the gene responsible for hemophilia is not dominant and it is located on one of the sex chromosomes, specifically the X chromosome.
Here is how it works:
Humans have two types of sex chromosomes, X and Y. Females have two X chromosomes (XX), while males have one X and one Y chromosome (XY).
For hemophilia to occur, the recessive gene must be present on the X chromosome.
In males: Since males have only one X chromosome, if they inherit the X chromosome with the hemophilia gene, they will have the condition because there is no second X chromosome to offset the effect.
In females: Because females have two X chromosomes, they need two copies of the recessive gene (one from each parent) to exhibit the disease. If a female has only one copy of the hemophilia gene, she will be a carrier but typically won't show symptoms because the other X chromosome, which does not carry the hemophilia gene, compensates.
In conclusion, hemophilia is inherited as a sex-linked recessive trait. This explains why it is more commonly observed in males than in females.