Human Biology - 4HB1 PearsonEdexcel

Heart Disease And Treatment

Gbogbo ọrọ náà

Coronary heart disease and high blood pressure are two of the most common circulatory disorders, and modern medicine treats them with a wide toolkit: physical interventions that restore blood flow directly, drugs that intervene at specific points in the body's chemistry, and, further afield, an entirely different kind of tool built from a single type of antibody produced in the laboratory. This topic covers all of it, from risk factors through to the mechanism of each named treatment.

You need to know how statins and plant stanol esters lower cholesterol by completely different routes, what beta-blockers and ACE inhibitors actually block, how systolic and diastolic blood pressure are defined, and how a monoclonal antibody is produced and used to detect or treat disease.

Ebumnobi

  1. Describe the causes, prevention and treatment of heart disease including the effect of diet and exercise, and the use of stents, artificial hearts and transplants
  2. Understand the problems associated with heart transplants
  3. Describe the use of statins and plant stanol esters in the treatment and prevention of circulatory disorders
  4. Understand the role of beta-blockers in the treatment of circulatory disorders, e.g. heart failure and angina
  5. Explain the terms systolic and diastolic blood pressure
  6. Describe the causes, prevention and treatment of hypertension
  7. Understand the role of ACE inhibitors in the treatment of high blood pressure
  8. Describe how monoclonal antibodies are produced
  9. Understand how monoclonal antibodies work to detect and treat diseases such as cancer

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Akwụkwọ Ọmụmụ

In coronary heart disease (CHD), fatty deposits rich in cholesterol build up as plaques inside the coronary arteries, the vessels that supply the heart muscle itself. As a plaque grows, it narrows the lumen and stiffens the artery wall, restricting blood flow to the heart muscle. A partial blockage reduces oxygen delivery enough to cause chest pain during exertion, called angina. A complete blockage stops blood reaching part of the heart muscle entirely, so that tissue cannot respire aerobically: this is a heart attack.

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Nnyocha Ọmụmụ

Ekele diri gi maka imecha ihe karịrị na Heart Disease And Treatment. Ugbu a na ị na-enyochakwa isi echiche na echiche ndị dị mkpa, ọ bụ oge iji nwalee ihe ị ma. Ngwa a na-enye ụdị ajụjụ ọmụmụ dị iche iche emebere iji kwado nghọta gị wee nyere gị aka ịmata otú ị ghọtara ihe ndị a kụziri.

Ị ga-ahụ ngwakọta nke ụdị ajụjụ dị iche iche, gụnyere ajụjụ chọrọ ịhọrọ otu n’ime ọtụtụ azịza, ajụjụ chọrọ mkpirisi azịza, na ajụjụ ede ede. A na-arụpụta ajụjụ ọ bụla nke ọma iji nwalee akụkụ dị iche iche nke ihe ọmụma gị na nkà nke ịtụgharị uche.

Jiri akụkụ a nke nyocha ka ohere iji kụziere ihe ị matara banyere isiokwu ahụ ma chọpụta ebe ọ bụla ị nwere ike ịchọ ọmụmụ ihe ọzọ. Ekwela ka nsogbu ọ bụla ị na-eche ihu mee ka ị daa mba; kama, lee ha anya dị ka ohere maka ịzụlite onwe gị na imeziwanye.

  1. Statins lower blood cholesterol by: A) Blocking cholesterol absorption in the gut B) Inhibiting a liver enzyme needed to make cholesterol C) Increasing heart rate D) Narrowing the coronary arteries Answer: B
  2. Which value is recorded when the ventricles contract? A) Diastolic pressure B) Systolic pressure C) Cardiac output D) Stroke volume Answer: B
  3. Beta-blockers reduce the strain on the heart mainly by: A) Blocking angiotensin-converting enzyme B) Widening the coronary arteries C) Blocking the heart's receptors for adrenaline D) Increasing blood cholesterol Answer: C
  4. In monoclonal antibody production, a hybridoma cell is formed by fusing a lymphocyte with a: A) Red blood cell B) Myeloma cell C) Phagocyte D) Platelet Answer: B
  5. A major advantage of using a monoclonal antibody to deliver a cancer drug is that it: A) Works on every cell in the body equally B) Targets the drug specifically to cells carrying the matching antigen C) Removes the need for any drug at all D) Cures the cancer immediately Answer: B

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